Research projects of Dept. of Digestive Surg. (Hepatobiliary-pancreatic group)

Cancer research

Diagnosis ・ Imaging diagnosis   Volumetry with SYNAPSE VINCENT (FUJIFILM) Evaluation of hepatic functional reserve by 99mTc-DTPA- garactosyl human serum albumin liver scintigraphy and Gd-EOB-DTPA     Carcinogenesis・progression・metastasis ・ Malignant potential of tumor （cancer stem cell, Treg, Notch signaling, HIF-1、HDAC、MTA-1、VEGF） ・ Mechanism of metastases-inplantation（Peg-IFN） role of SDF-1/CXCR4 axis in liver metastasis ・ Carcinogenesis of the liver（Hybrid analysis by DNA-miRNA micro array, DMA methylation array）     Cancer therapy ・ Radiation sensitizing agents：（HDAC inhibitor） ・ Anti cancer agent（HDAC inhibitor, Peg-IFN） ・ Immunostimulant of “KAMPO” medicine（Ten strong tonic herbs decoction） ・ Postoperative stimulant for gastrointestinal tract（Rikkunsito, Dai-kenchu-tou） ・ Operation   Laparoscopic surgery (hepatectomy, pancreatectomy) Splenectomy (inprovement of liver and immune function) Usefullness of Grisson cauterization, and clamping method in liver segmentectomy (HyperEye navigation) Hanging maneuver method in liver resection・clipless technique

Regeneration / Organ failure

Metabolism and nutrition ・ Immunonutrition（MEIN）     Cytoprotection ・ Small-for-size graft・a measure for massive liver resection（Catechin, α-lipoic acid, HBO, Keep Fresh, IFN, ICKT, MEIN, splenectomy） ・ Influence of Cetuximab, Sorafenib, Bevacizumabfor on liver regeneration ・ Anti NASH（suppression of ER stress）     Transplantation ・ Liver/pancreas Tx（CD25/4+ T-cell, Notch ligand） ・ Adipose tissue derived regenerative cell Tx ・ Treatment and monitoring strategies for patients with HLA-DSA     Aging ・ Influence of aging on liver regeneration and fibrogenesis