Research projects of Dept. of Digestive Surg. (Gastrointestinal group)

Cancer research

Carcinogenesis・extention・metastasis 　 Relationship between anti-aging gene (sirtuin) and gastrointestinal cancer: SIRT1,SIRT3 Expression of Sonic hedgehog pathway and tight junction proteins, stemness markaers (CD133, CD44, EpCAM, Oct 4, Nanog) Investigation of expression of AID, PKCι, THBS1, HDAC1, MTA1, HIF-1 in carcinogenesis of gastrointestinal tract Anti-tumor effect of hADSC Suppression of distant metastases afterradiation therapy byregulation of reg T cell Suppression of cell growth by LED lighting

Diagnosis

Imaging diagnosis 3D-CT, MIP, Virtual colonography Computer assisted diagnostic system for digestive cancer Relationship between tumor marker, prediction of chemo-radiation therapy and PET-CT (SUVmax) for colorectal cancer     Genetic diagnosis Prediction of sensitivity for CRT by Focused DNA array: miR-223

Terapy

Preoperative chemoradiation therapy for advanced lower rectal cancer with S-1+Oxaliplatin+Bev Relationship between expression of THBS1 and Paclitaxe＋TS-1combined terapy for advanced gastric cancer Prediction of sensitivity for CRT by Focused DNA array for advanced lower rectal cance Radiation sensitizing agents：Oridonin、TPI、HDAC inhibitor Change of electric potential of intestinal mucosa in Bacterial translocation by Ussing chamber Effect of DKT in prevention of bacterial translocation Investigation of regulative mechanism of paracellular route in BT and development of preventional method Investigation of relation ship between anti-inflammatory effect of DKT and change of microbiome of intestine

Bariatric therapy

Effect of bariatric surgery for DM and obesity in rat model Investigation of ethiology of metabolic syndrome by investigation of adipose tissue Investigation of relationship between metabolic syndrome and carcinogenesis, extension of cancer